Bringing NLM to You

Guest post by Andrew Wiley, Video Producer, NLM Office of Communications and Public Liaison.

Before the COVID-19 pandemic, visitors from all over the world came to NLM for free, in-person, guided tours to learn about the largest biomedical library in the world. Visitors ranged from members of the public to students, educators, scientists, and nurses. They were introduced to many of NLM’s exciting research and information resources, such as the Visible Human Project — a library of digital images representing the complete anatomy of a man and a woman allowing visitors to discover a new perspective on the human body. Visitors could also explore the NLM Data Center, which houses the vital databases visitors know and love, such as PubMed, ClinicalTrials.gov, MedlinePlus, and GenBank.

NLM is not your typical library. During tours, visitors could interact with the investigators in our NLM Intramural Research Program who are using computational biology and computational health science approaches to solve biological and clinical problems. Visitors could also descend into the underground stacks to see medical librarians scanning the world’s largest collection of scientific and medical literature. They could also view some of the world’s oldest and rarest medical books in NLM’s extensive historical collections — discovering just a few of the features that makes NLM so unique.

While the pandemic put a temporary stop to our ability to continue with physical tours of NLM, we know that visitors are eager for a virtual alternative. That’s why we created our new NLM Welcome Page.

This is where you can start your virtual tour and explore NLM’s offerings and resources. Here you can embark on a journey to explore some of what NLM has to offer through webpages that guide you from the world’s richest collections of historical material to the most cutting-edge data of the 21st century.

We want you to be able to experience NLM’s past, present, and future, and continue to see how NLM’s research and information services directly support scientific discovery, health care, and public health.

NLM is committed to serving scientists and society. What would you like to explore at NLM?


Photo of Andrew Wiley

Andrew Wiley is a video producer and writer for NLM’s Office of Communications and Public Liaison. Before joining NLM in 2008, Andrew produced local television in Frederick, Maryland and worked as a video journalist for The Frederick News-Post.


Video Transcript (below):

Hello, I’m Dr. Patti Brennan. I’m the Director of the National Library of Medicine.

As a nurse and an industrial engineer, I’ve spent my career making sure that information is available to help people make everyday health choices and to support biological and medical discoveries.

At the National Library of Medicine, we provide trusted information to scientists, to society, and to people living every day with healthcare challenges.

For over 200 years, the National Library of Medicine has been a partner in biological discovery, clinical care decision making, and health care choices in everyday living. We began humbly as a small collection of books in the 1800’s and now have grown to massive genomic databanks accessible worldwide every day by millions of people.

As one of the 27 Institutes and Centers here at the National Institutes of Health, we have three primary missions:

  • First, we have researchers that develop the tools that translate health data into health information and health action.
  • Second, we serve society by collecting the world’s biological and biomedical literature making it useful to scientists through our PubMed resource, and to everyday people through MedlinePlus.
  • Finally, we have a mission for outreach to make the National Library of Medicine’s resources accessible to everyone through our 7,000 points of presence around the United States. We make sure that the resources of the National Library of Medicine are available through public libraries, through hospital libraries, and in schools and clinics.

Making all of the resources of the National Library of Medicine available to the public requires a very large workforce. We have over 1,700 women and men working here. We have librarians, computer scientists, researchers, and biological scientists. We have individuals who understand clinical care, and who understand how to educate the public. We work together to make sure we can deliver—24 hours a day, 7 days a week—trusted health information.

Thank you for visiting us today. We hope you will join with us as we begin our third century bringing health information to scientists and society, accelerating biomedical discovery, improving health care, and ensuring health for all globally.

Ending the HIV Epidemic: Equitable Access, Everyone’s Voice

A guest post by Amanda J. Wilson, Chief, Office of Engagement and Training; Leigh Samsel, NLM Planning and Evaluation Officer, Office of Strategic Initiatives; and Elizabeth A. Mullen, Manager of Web Development and Social Media, History of Medicine Division, National Library of Medicine at the National Institutes of Health.

This year’s theme for World AIDS Day is Ending the HIV Epidemic: Equitable Access, Everyone’s Voice. As the world’s largest biomedical library, NLM has a long history of supporting NIH’s efforts to end the HIV epidemic by providing equitable access to trusted biomedical information, supporting biomedical research, and highlighting the historical, social, and cultural context of this research. Expedient, reliable, free public access to NLM’s trusted biomedical information resources and literature collections advances the knowledge and treatment of HIV/AIDS worldwide, helps progress research to end the HIV epidemic and improves the health of people living with HIV.

Improving HIV/AIDS Health Information Access

NLM integrates multiple types of HIV literature, sequence, testing, and clinical trials data into a portfolio of resources that enables researchers to easily find related information and robustly supports global research to end the HIV epidemic. Free public access to citations to the scholarly literature is provided through NLM’s PubMed and Bookshelf, while free access to full-text is provided through PubMed Central and NLM Digital CollectionsGenBank and the Sequence Read Archive allow researchers to deposit and access publicly available DNA sequences, including HIV experimental and clinical genome sequences. NCBI Virus makes HIV and other virus sequences from RefSeq, GenBank, and other NLM repositories available. The HIV-1 Human Interaction Database includes information gleaned from literature about the interaction between human and HIV-1 genes and proteins.

NLM also provides a rich resource of easy-to-understand online health and wellness information available in English and Spanish via MedlinePlus. Among its wealth of content, MedlinePlus contains several HIV/AIDS topical pages. NLM supports an equitable distribution of information by providing resources and support to strengthen skills and literacies needed to access and use biomedical information for those affected by HIV/AIDS. The Network of the National Library of Medicine provides free health information training, from webinars to instructor-led classes to on-demand tutorials. Additional trainings on a variety of topics are added weekly.

A Long History of Support

NLM’s engagement and collections activities strive to capture the many voices in and around the HIV epidemic. A key historical partnership for engagement with the NIH Office of AIDS Research was the HIV/AIDS Community Information Outreach Program; beginning in 1994 as a resource for community-based organizations to improve the knowledge, skills, and technical means to access and provide the latest authoritative prevention, treatment, and research information electronically. The current iteration of the program concludes this month with 200 plus organizations conducting more than 350  projects in 38 states providing training, communications campaigns, and enhanced products and apps to raise awareness of HIV/AIDS information and discoveries over the 40-year history.

NLM has been collecting publications and archival materials related to HIV/AIDS since the first Morbidity and Mortality Weekly Report on the topic was issued in June 1981. The NLM HIV/AIDS Web Archive offers more than 150 websites documenting the biomedical, clinical, cultural, and social aspects of HIV/AIDS in the early 21st century. This month you can look for new additions and resources.

World AIDS Day 2021

Screen shot of NLM's History of Medicine Division's exhibit entitled "AIDS, Posters and Stories of Public Health"

This month, to help mark World AIDS Day, NLM will launch a new online exhibition—A People’s History of Pandemic: AIDS, Posters, and Stories of Public Health. The NLM exhibition will cover the archive of public health posters about AIDS rooted in the cultural output of artists, activists, and community workers. Their work, specifically the use of personal narrative as a visual-art strategy, along with language and the collective process of creating AIDS posters, continues to broadcast the message that, 40 years after the crisis began, attention to AIDS has not diminished. In mid-December, NLM’s Profiles in Science, will release a curated collection of digitized primary source materials related to the United States National Commission on AIDS, dating from the mid-1980s through the early 1990s. Learn more about the diversity of NLM’s historical collections related to HIV/AIDS on Circulating Now.

As we mark this year’s World AIDS Day, NLM is proud to continue its efforts to provide global access to trusted resources; share the voices of those affected by HIV; and provide the foundation for researchers, clinicians, patients, and families to engage and answer the call to end the HIV epidemic.

Photo of Amanda Wilson

Amanda J. Wilson is Chief of the NLM Office of Engagement and Training (OET), bringing together general engagement, training, and outreach staff from across NLM to focus on NLM’s presence across the U.S. and internationally. OET is also home to the Environmental Health Information Partnership for NLM and coordinates the Network of the National Library of Medicine.

Photo of Leigh Samsel

Leigh Samsel, MS, is responsible for formal reporting of NLM activities and for providing staff leadership to strategic planning activities. Leigh is currently serving as NLM’s AIDS Coordinator to the NIH Office of AIDS Research.

Photo of Elizabeth Mullen

Elizabeth A. Mullen, MS, is Manager of Web Development and Social Media for the History of Medicine Division (HMD) and Managing Editor of Circulating Now, a blog featuring new research, curatorial insights, and news about NLM’s historical collections.

Using Comparative Genomics to Advance Scientific Discoveries

Guest post by Valerie Schneider, PhD, staff scientist at the National Library of Medicine’s National Center for Biotechnology Information, National Institutes of Health.

In a post from earlier this year, A Journey to Spur Innovation and Discovery, I shared news of an exciting NIH-supported NLM initiative, now known as the NIH Comparative Genomics Resource (CGR). CGR, which supports eukaryotic organisms, is modernizing NIH resources and infrastructure to support research involving non-human organisms. This initiative will improve the data foundational to analyses that rely on comparisons of diverse genomes in NLM databases, increase its connectivity to related content, and facilitate the discovery and retrieval of this information. Just as researchers look to the data from these organisms to teach them about a wide range of fundamental biological processes underpinning human health, NLM relies on the research community to help inform the development and delivery of organism-agnostic core tools and interfaces for CGR so that it can best support these analyses.

Stakeholder feedback and engagement is central to the vision and ethos of the NLM Strategic Plan 2017-2027. Since the plan’s inception, NLM enterprises undertaken in support of our three primary goals have placed heavy emphasis on community connections in both their planning and execution. Likewise, understanding stakeholder needs is a fundamental element of CGR. With more than 19,000 genomes from over 8,500 species (excluding bacteria and viruses) found in our Assembly database, it’s clear that CGR’s user base will hail from a large and diverse collection of research organism communities. Within each community, there is diversity in the role CGR will play due to variability in the amount of genomic sequence available, as well as the existence of organism-specific data resources, such as community knowledge bases. Data consumers, themselves, are a heterogeneous population and represent different levels of research interests, education, bioinformatics expertise, and analysis needs.

CGR is using a multi-tiered and multi-faceted approach to ensure stakeholder requirements are understood and appropriately prioritized throughout the project duration. CGR is working to identify community-supplied genome-related data that can be integrated to enhance content supplied by NLM. Two governance bodies are playing important roles in this effort. A trans-NIH CGR steering committee provides strategic oversight by guiding CGR with respect to the priorities of NIH institutional stakeholders, and an NLM Board of Regents CGR working group is charged with helping engage with the scientific community and enlist them as partners in the development effort. Working group members have expertise in topics relevant to the CGR initiative, such as comparative genomic analysis, emerging large-scale genomics approaches, organism-centered research into general biological or disease processes, biological education, and workforce development.

We are developing a presence for CGR at scientific conferences and workshops to encourage partnerships with members of research communities and connect with attendees. A CGR-related talk given at the BioDiversity Genomics 2021 conference in September introduced a new cloud-based tool for improving genomic quality to be released in 2022 and identified researchers to serve as beta testers. Additional targeted outreach will be held independent of conferences to gather feedback and inform development.

The CGR project utilizes an iterative development process in which user testing is an integral element. Feedback gathered through these testing exercises is incorporated into the next development cycle. This approach ensures we remain engaged with the CGR target audience throughout the project by understanding their needs and providing a resource that is valuable to their research pursuits. For example, recent user testing of a prototype Basic Local Alignment Search Tool (BLAST) database engineered to support sequence queries seeking a broad distribution of organisms in the results taught us about other content that will need to be provided for proper interpretation of results.

NLM is poised to learn great things from our users as part of the CGR project. You can learn more about engagement opportunities by contacting us at info@ncbi.nlm.nih.gov. We value your input as we continue this journey together.

Valerie Schneider, PhD, is the deputy director of Sequence Offerings and the head of the Sequence Plus program. In these roles, she coordinates efforts associated with the curation, enhancement, and organization of sequence data, as well as oversees tools and resources that enable the public to access, analyze, and visualize biomedical data. She also manages NCBI’s involvement in the Genome Reference Consortium, the international collaboration tasked with maintaining the value of the human reference genome assembly.

Request for Public Comment: Seeking Input on Nationwide AI Research Resource Implementation Plan

Guest post by Lynne E. Parker, PhD, Director of the White House National Artificial Intelligence Initiative Office, and Erwin Gianchandani, PhD, National Science Foundation Senior Advisor for Translation, Innovation, and Partnerships

The White House Office of Science and Technology Policy and National Science Foundation are looking for your input to shape the work of the National Artificial Intelligence Research Resource (NAIRR) Task Force. This Task Force is taking on a critically important initiative – building an implementation plan for a national infrastructure that would democratize access to artificial intelligence (AI) research and development (R&D).  

As directed by Congress in the National AI Initiative Act of 2020, the Task Force is serving as a Federal advisory committee to help create a blueprint for the NAIRR, which is envisioned as a shared computing and data infrastructure that would provide AI researchers and students across all scientific disciplines with access to computational resources, high-quality data, educational tools, and user support. This capability would help make AI R&D accessible to all Americans by lowering the barriers to entry for traditionally underserved communities, institutions, and regions. It would also fuel innovation by making it easier than ever before for Americans to pursue bold, visionary applications for AI.

The Task Force will provide recommendations for establishing and sustaining the NAIRR, including technical capabilities, governance, administration, and assessment, as well as requirements for security, privacy, civil rights, and civil liberties. The Task Force will submit two reports to Congress presenting a comprehensive strategy and implementation plan: an interim report in May 2022 and final report in November 2022.

To get this right, we want to tap into the deep technical expertise of the community and bring in a range of perspectives. We invite you to submit a response to our Request for Information before the comment period closes on October 1, and ask that you spread the word. This effort could set us on the path to transform our nation’s ability to harness AI across fields of science and engineering and economic sectors, and your insights could help shape our approach.

We appreciate your contributions and look forward to receiving your input.

Dr. Parker is the Founding Director of the National Artificial Intelligence (AI) Initiative Office and Assistant Director of AI in the White House Office of Science and Technology Policy (OSTP).  In these roles, she leads national AI policy efforts and coordinates AI activities across the Federal agencies in support of the National AI Initiative.  Dr. Parker is a professor of computer science at the University of Tennessee, on assignment to OSTP. She received her PhD from the Massachusetts Institute of Technology and is a Fellow of the American Association for the Advancement of Science and Institute of Electrical and Electronics Engineers.

Dr. Gianchandani is the National Science Foundation (NSF) Senior Advisor for Translation, Innovation, and Partnerships. For six years, he was the NSF Deputy Assistant Director for Computer and Information Science and Engineering. In this role, he contributed to the leadership and management of NSF’s CISE directorate, including formulation and implementation of the directorate’s $1 billion annual budget, strategic and human capital planning, and oversight of day-to-day operations. He received a BS in computer science and MS and PhD degrees in biomedical engineering from the University of Virginia.

Going Back to School Safely

Guest post by Diana W. Bianchi, MD, Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health

Originally released on the Director’s Corner blog.

As schools across the United States begin to resume full-time, in-person education, I am hopeful that this academic year may be a more typical one. The in-person school environment and the wide range of services offered there are critical for the development and well-being of our nation’s young people. Without in-person schooling, many children miss out on school-based meals, speech or occupational therapy, and after-school programs. Loss of such services disproportionately affects minorities, socially and economically disadvantaged children, children with disabilities, and those with medical complexities.

Generating robust scientific data to inform policies to return children to the classroom safely and equitably during the ongoing COVID-19 pandemic is of paramount importance not only for children, but also to allow their parents to return to work. We now have safe and effective vaccines available for adults and children ages 12 years and older, as well as established public health measures to prevent transmission of SARS-CoV-2, the virus that causes COVID-19. Yet the emergence of the more transmissible delta SARS-CoV-2 variant and the rising COVID-19 cases across the country remind us that we must remain vigilant and adaptable to changing circumstances.

NICHD manages the Safe Return to School Diagnostic Testing Initiative, launched earlier this year as part of the NIH Rapid Acceleration of Diagnostics-Underserved Populations (RADx-UP) program. This initiative addresses the needs of children with unequal access to COVID-19 testing and who face barriers to attending school remotely, including those who do not have adequate equipment, internet access, or adult supervision at home.

The RADx-UP Return to School projects combine frequent COVID-19 testing with proven safety measures to reduce the spread of SARS-CoV-2. They also are exploring the influence of vaccination for eligible staff and students, addressing vaccine hesitancy, and seeking information on circulating SARS-CoV-2 variants and breakthrough infections. Funding for the first set of projects was announced in April, and additional projects were funded in July. Currently, 16 projects are ongoing at schools across the country, including public, charter, tribal, early education, and special education schools. Participating schools serve racially and ethnically diverse populations, including African Americans, American Indians/Alaska Natives, Latinos/Latinas, Asian Americans, and Native Hawaiians and other Pacific Islanders. Critically, several projects include children with medical complexities and/or intellectual and developmental disabilities who may not be able to use COVID-19 mitigation measures such as wearing masks or social distancing.

On August 9, NIH hosted a virtual workshop that brought together RADx-UP Return to School investigators and other researchers conducting school-based research on COVID-19 diagnostic testing to present data acquired to date, learn from each other, and support the safe return of children to in-person school.

Among other topics, workshop participants discussed the critical importance of engaging local communities in this research. Communities need access to the most up-to-date scientific evidence to weigh the benefits and challenges of implementing different COVID-19 mitigation strategies. Scientists need community input to understand the attitudes, knowledge, and barriers that may influence individual choices to enroll in COVID-19 testing programs and return to in-person learning. By working together, we can ensure a safe return to school for all.

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